Dear Michael, I once went to Pompeij with somebody who was careless enough to fell in love with me. We got lost, after the Pompeij necropolis was closed and walked around through the darkness, expecting every second that a time leap might send us back to year 79 A.D., when the erupting Vesuv burried the town and all its people underneath. The red-orange background is from a photo we did there at sunset, the mysterious moon in the foreground is from tonight.
Take good care,
/ghazal

Dear Michael,

All the big stars, i.e. those with a mass exceeding the sun’s mass by a factor of 1.3, gain most of their energy by a hydrogen-fusion reaction that involves a catalytic cycle, known as the Bethe-Weizsäcker or CNO-cycle.

During this reaction cycle,  protons (i.e. hydrogen nuclei) are added four times into a cycling reaction that converts carbon through various nitrogen and oxygene isotopes back to carbon, while releasing helium as the net reaction product and, of course, the enormous amount of energy which fuels the star.

This cycle in its logic resembles the citric acid cycle, during which all aerobic organisms convert energy from nutrients (i.e. carbohydrates, fat, and sometimes proteins) into ATP.  Similar to the Bethe-Weizsäcker cycle, successive transfer of protons (in this case released from water) are an important feature of this energy conversion.

But beyond this similarity in the reaction cycle, the CNO-cycle (providing stars with their enormous energy) and the citric-acid cycle (providing energy to living organisms) are connected by a much more fundamental link:  The Bethe-Weizsäcker CNO cycle is the first reaction in the formation of our universe that produces Oxygene and Nitrogene from Carbon and Hydrogene (Carbon is directly produced by 3-alpha fusion of Helium nuclei).  And it is these three elements, namely Carbon, Oxygene, Nitrogene and Hydrogene, that are the basic elements of all living matter. All Carbohydrates are made of C, H and O, as are all fatty acids. All proteins are made of C, H, O, and N  (with a trace of Sulphur).  And essential element that is missing is Phosphorus, an integral constituent of DNA and RNA. But in molar amount, it is much less than C, H, N, and O.

So we have to acknowledge that the main constituents of our body (and of any other living organism as well) were a by-product of the stars engine.

Or as Crosby, Stills, Nash and Young put it in their songs lyrics:

We are Stardust

Well I came upon a child of God, he was walking along the road
And I asked him tell where are you going, this he told me:
(He) said, I’m going down to Yasgur’s farm, going to join in a rock and roll band.
Got to get back to the land, and set my soul free.
We are stardust, we are golden, we are billion year old carbon,
And we got to get ourselves back to the garden.

Well, then can I roam beside you? I have come to lose the smog.
And I feel myself a cog in something turning.
And maybe it’s the time of year, yes, said maybe it’s the time of man.
And I don’t know who I am but life is for learning.
We are stardust, we are golden, we are billion year old carbon,
And we got to get ourselves back to the garden.

By the time we got to Woodstock, we were half a million strong,
And everywhere was song and celebration.
And I dreamed I saw the bomber jet planes riding shotgun in the sky,
Turning into butterflies above our nation.

We are stardust, we are golden, we are caught in the devil’s bargain,
And we got to get ourselves back to the garden

————————————————————————————————-

Ghazal, my Dear,  I always believed that you came from another star. What you wrote above shows that you brought from there some interesting ideas with you.

Take Care, my Dear

Michael

PS:  I think we also have something in common, in our dialogue that is going on for about 3 years now.  Whereas I always tried my best to misunderstand you, to fill the empty spaces in your messages with a meaning that perhaps was never there, you in contrast always managed to not understand anything from what I wrote. When I imagined that there are words between the empty spaces in your letters, you decided that the long sentences from me were void of any meaning.  How long can this go on ?

Hello, my name is Nofretete, and I was born in Luxor in Egypt.
1912 some archeologists recovered me from this dark grave in the earth and brought me back to light. I, who together with my beloved husband Echnaton were so much fascinated by the divine nature of the sun had to spend 3400 years in the dark. When I was recovered and brought to Berlin, this not only caused a real Egyptomania and Nofretete-cult amongst the ordinary people, but the sun itself started to shine brighter and stronger for happiness to have me back.

The Egyptians were always afraid of my beauty. 3400 years ago they hated my preference of the sun against all the single, little minor gods they were worshipping. Thats why they banned my statue and burried me deep under ground. After the German archeologists under Ludwig Borchardt excavated me 100 years ago in the meter deep dust in Amarna, and brought me back to sunshine, the Egyption authorities several times attempted to get hold of me. They ordered reviews from French lawyers that should proof how the Germans had violated a contract with Egypt and insidiously betrayed them by highjacking me to Berlin. I have to admit, that my escape from Egypt to Berlin did not happened against my own will: Without exchanging words, both Borchardt and myself understood that the Berlin New Museum would provide a more adequate place for me than an Egyptian dust bin. We were afraid that in Egypt, they again would try to hide my beauty from the peoples eyes.
Now, 2012, 100 years after my rebirth, they introduce in Egypt the Sharia, ordering every woman to hide her face and her beauty. Returning to Egypt, wouldn’t they put me under a hijab or a burka, before showing me in the public ? Or will the Salafists who just occupied a couple of parlament seats and  governmental posts attack me altogether, destroy me as they did with other statues in Afghanistan and in Mali, because they fear that people will worship my beauty ?
In Berlin in the New Museum, people from all over the world come only to see me, and yes, they worship my beauty. They like me, and I like them, and therefore I will stay in Berlin forever. I am nobodies property, I belong to the entire mankind. But in Berlin they always took care of me, and I know they will do so forever. During the bombings of the 2. world war, when the entire city turned into a pile of debris, they found a safe shelter for me somewhere far away in a mountain village. They were so intrigued by Nofretete, that first  emperor Wilhelm II and later the East-German government (who lost me to West-Berlin) both ordered identical copies of my statue.
I am nobodies property, not the Germans and not the Egyptians. But I am and will stay a Berliner. The local people call me a “Berliner Göre”, and although this sounds turkish, it is their slang for “naughty little girl”. Although this of course is a (typical Berlin) understatement of my beauty, I can life with it.

Ghazal my dear,

What is age, and what is aging, if everyone uses a different measure for this. This came to my mind when I did another picture of the moon tonight. Tonight it was once again the night of the Persides meteor shower. But since nothing could top the spectacular meteor that we saw together with you at the same night in 2010, I put more attention to the moon again (1). A year ago at the same night, we have been at the Bulgarian blacksea coast, and then the Persides night fell together with the full moon. This year, however, the same day in the year (11th to 12th of August), the moon looked completely different.

Is there a final take-home message from this post for you, Ghazal ? Maybe you will find one.

Take Care my Dear

Michael

Footnotes:

(1) Surely you know that the Moon symbolizes the pure, innocent beauty in Persian classicla poetry. This is independent of the exclusive role of the Sun in ancient, pre-islamic Persian culture, philosophy and science. But because poetry is very much influenced by arabic traditions, their spiritual preference for the moon as symbol in religion and arts got access into the poetry of Hafez, Rumi, Atta and Omar Khayyun.

(2) The Persides Meteor shower lives up to its name: same as the Persian people do, it follows precisely the sun’s calender. I guess that it follows in a precise and constant time after Persian Nouruz.

(3) Initially I could not figure out, if the name of the company GLOBAL-SHINING was referring to the moon or the sun. But now that I know that it is a Hongkong based company, I guess they even mean the Shining Stars.

(4) I guess Mr. Ho wont mind having his business address published here on my blog. But it might further promoted his excellent business. Just that Tsuen Wan does not have a postcode might discourage Hongkong tourists to drop into his store and buy camera displays.

but suddenly, at around 3:22 min a very short picture showed a neon-sign pointing to a “Hotel Evin”, that convinced me it is Iran. Would like to know, is there really a Hotel in Teheran that carries the same name as the prison notorious for all the violence ? Which hotel owner would call its business after a place of death and violence ? And who are the customers booking in a hotel with this name ?

I heard the most horrible reports about Evin and other prisons, people in particular political prisoners are tortured there with pure saddism using physical and psychic violence in the most inhuman manner. People are killed there systematically. I feel anger imagine somebodies calls a hotel after this place of horror. When we visited last year with Shava the concentration camp near Munich (think it was called Dachau), at least people respected the memory of all those who lost their lives there. Nobody would consider calling a Hotel after this place Dachau, don”t you think so ?

Hope everything is fine with you, Take Care
/ghazal

Do you remember that we once talked about UV-exposure and skin pigmentation ? You send in November some papers about it, and how this is regulated.
There is an other aspect, and this relates to inherited genetic differences (i.e. a problem that is similar to your MSc project and the search for germline variations). Recently I found an interesting article that came up with a nice explanation for the reduction of the skin pigmentation during the migration of humankind to the northern hemisphere (from their origin in Africa about 100 000 years ago).

The reason is that UV-radiation has not only a detrimental effect (by damaging the DNA and potentially causing skin cancer, as you perhaps know better than anybody else), but it is also essential for the production of vitamin D in our body (important for skelettal development and other biological processes).
If humans during their migration from africa to the north would have kept their dark skin, the lower UVB level in europe would have caused a severe vitamine D deficiency. Therefore, reducing skin pigmentation genetically gained a survival benefit (since with less dark skin, more UVB reaches the dermis and more vitamine D can be produced).
Therefore, if dark coloured people move to the northern hemisphere for longer time, they might start to suffer from vitamine D deficiency. There is only one exception, and these are the inuit living in northern Canada and Greenland. They have relatively dark skin, but live with low UVB level. Their only way to get sufficient vitamine D is by eating raw meat from seals (in particular their liver is full of vitamine D).

The full paper about this is here:

I hope, Ghazal, you will have a sunny weekend, so you get enough UV to produce vitamine D.
You are lucky anyhow, since your light skin is the best condition to live in the north and stay healthy.

Take Care, Enjoy everything

Michael

PS: Have I already wrote you “Thanks” for the Nowruz power-point presentation that you send ? I think I forgot, sorry for this.

PPS: There is an iranian movie in the cinema here, called “Darbareye Ely“. I will probably go and watch. Have you seen it or heard about ?

Tonight I have something very unusual to tell you. It is so unusual, because it is something commercial, about shopping and beeing happy to have found something very useful.

I know you got excited now, don”t you ?
You can”t stop reading any more, right ?
You wan”t to know what it is, don”t you ?

(You are really sweet !!)

But be aware: it again has something to do with you and me !! (just a little material and technical aspekt in addition to all the happiness that you brought to me by your shear presence).

It is about the little Smartphone-Adapter-Plug that somehow broke
(Could be that it broke because you poked and bended and cut it, since you thought it is a piece of your fingernail ?) It is not so important, how it broke and why, it is just the adapter, its wasn”t the Smartphone”s heart that broke, I know you wouldn”t be able to do this, you are too much an angel to break hearts.

Well, I searched this special Hewlett Packard Smartphone shop today and guess what:
I found the adapter (same colour: black, as you prefer for men. No pink. If there would be a pink one, I would have bought both of them: one for me and a pink one for you in case you need the GPS again).

And what is so amazing (and for this I have to be grateful to you, since I would have never found this):
This little adapter thing comes together with a SOLAR ENERGY RECHARGER !!!!
This means, I can not only mount the Smartphone to the car again, but now I can recharge it in the sun !!!

It will always remind me of this summer 2010, which in my memories will always remain as the most sunniest summer ever.
Although the nights in the moon-light and under the meteor showers and the stars were amazing as well. Who knows, maybe the light of the stars and of the moon is sufficient to recharge the phone with this little crazy adaptor.

Ghazal, my dear, tell me what you need to recharge your life battery !
You are always so calm, sometimes I”d like to make you explode, to beat me in the face, to shout on me, to see you holding a gun on me (of course only with bullets that hurt, but don”t kill), only to see that you are full of energy.

But this probably would change everything, you would not be you anymore, and for me the illusion, that you are the grown up daughter of the persian family that I met 20 years ago in Berlin would fall down in pieces.

Are you o.k., happy (I know, its hard to tell. One always could imagine beeing a little bit happier).
I permanently feel guilty, sometimes feel as if I have taken you as hostage here in Munich, keeping you in this single room in the guesthouse like a nun in an eremitage.
I only feed you with words, but they can not get rid of your loneliness.
At least I should have given you a cat, such one as Holli Golightly had in “Breakfast at Tiffany”s”. It could lean on you in the evening, and purr if you crawl its fur. It would jump on you lap, when you watch a movie or listen to some music.

Wish you a pleasant night, funny dreams, sleep well

Michael
……………………………………………………………………………………

michael,

im glad you found a better adapter for your phone! didnt know that such thing exsist, an adapter that charges the phone with sun. interesting.

haha i dont want to hold a gun against you and shoot, i will stay calm.think it is better. dont think my mum thinks im calm at home.

dont worry about me. i enjoy unterschleissheim. the guesthouse. i feel so relaxed and calm when i am here. and i am so happy with everything.
cats are cute, but only when they are babies.

see you tomorrow

/ghazal

…………………………………………………………………………………..

See you tomorrow, my Dear.
Thanks to confirm that you enjoy and relax. Even if you would have told me this already a million times: I”d like to hear it once again !

Sleep well, dream something happy.

Michael

PS: Ghazal, my Dear, Can you imagine the head-lines in the newspaper:
“MSc student shoots down its supervisor”. This would make us sooooo famous.

Anyway, have a sweet night, but this time I think I have to take care :-}

I hope you are doing well and feel o.k.
Is it quiet now in the Lab ? Usually this is the best time to concentrate on the project. I hope so much that you find some intellectual satisfaction with the project and not have to consider it as a hard burden and a duty to fulfill.
I prepared some text about the mapping, the markers, the mouse strains and linkage. It should somehow fit into the thesis structure (as much as I remember it was part 2 or so). Just break it apart into the several sub-headings.

And of course, if you find in the text something difficult to understand or wrong or strange, please write me back. I very much like the intellectual conversation with you and I learn a lot from your questions as well.

I will also send you something that explains the animal experiments (the older ones we did years ago and the JF1 x FVB crosses). Was Prof. T. already around ?

I think of you and your aristocratic character, that is so much different from the people here around which are very loud and miss any sense of ellegance. This is usually what one can expect at a beach,but the kids like this and therefore I have to decline.
I”m waiting to see you next week.

Take Care,my dear

Michael

……………………………………………………….

Hi Michael!!

T. has not been here yet. I think he chose this week on purpose. Both
you and M. are on vacation.
It is a bit quiet yes. I put aside the labwork yesterday and today to
sit and read and write. btw, the sequencing worked!! im happy. me and
claudia will maybe analyse the data later today.
it is not a burden to do this project. everything has been good so far.

I do not know how to thank you for writing so much for me. i have
written a bit about the mapping and microsatellite and QTL. but it was
not as much as yours. so thank you. you should not do this on your
vacation. just go and have fun. right now i am concentrating at the
first part with chernobyl and thyroid cancer.

take care and see you next week!

/ghazal

………………………………………………………
Ghazal my Dear,

Good to hear that you managed so well to continue with the project and the thesis during this week. Good luck with the sequence analysis,hope you and C. find some interesting variations between the two strains.
I attache a piece of text that describes the rational for using the JF1 and the FVB/N strain in this project. Please double-check if any of the chromosomal loci or gene names are consistent with what you wrote before. Also, in case you find any other discrepancies with the other text-pieces,please mark it in red and we will go through when I am back.

Ghazal, please don”t feel obliged to say “Thank you” for these small pieces of text. It is my very duty as a supervisor to help you with this. It is you who is doing the sophisticated and very decent experimental work day-by-day, without complaining that it is getting boring. Therefore,it is in fact me who must be extremely grateful. Don”t forget this, please.
And what is maybe even more relevant, that you always have this endless patience with me, if I come around and require that you spend the time after work with me. No MSc student has the commitment of going to the movies or to an exhibition or to the beach with its supervisor, or attend with him a concert or watch the meteor shower in the middle of the night. You could have in fact complaine with Prof. T. right from the beginning and ask for another project or another supervisor. I know I was always a bit violently when I asked you to meet me after work,and who knows how often I have disturbed your planing for the evening when you wanted to read or write something for the project. Therefore,it is the least I can do to help you to get everything together know for the thesis, it is a very small compensation for all the nice days and moments you have been with me and for having been always so patient and listened to my silly stories and telling me something from you. You could have easily send me to hell, you never did (I hope you dont wish you could have done this, but you did not wanted to risk your project).

Ghazal, you will see at the end (and everybody will agree) that a successful MSc project does not need this archetypical and hirarchical relation between student and supervisor, but it also can be done if there is a (sort of) frienship.
For me,to be honest, you are too much a mystery to call this a simple friendship.

I wish you a pleasant evening, a relaxing night, and nice dreams.

Michael

PS:How is your watch doing ? I hope that “No news are good news” and it runs precisely now, since you gave it a bit more freedom around your arm.

………………………………………………………
hi michael,

i think i found one mutation on the third exon.

yes u are right i could ask prof. t. for another project (and he would not give me another since i already tried in the beginning). but i enjoy it here i would not do it. u could also be a bad supervisor and not wanting to help. so i am grateful.

i send u a text with some questions. answer just if u have time. no hurry.

my watch is suprisingly doing great!its strange.

have a good day!!
/ghazal
……………………………………………………….
Ghazal my Dear,

Congratulations for finding a sequence variation in FGF10 in one of the mouse strains..
You could check (using Ensembl and search for FGF10 in mouse,and click on the left panel on the button for variations) if this sequence alteration was already described in any other mouse strain. You should also check if it might cause an amino-acid change, in case it is still part of the coding sequence (I remember large parts of exon 3 were already 3″ UTR. Maybe you find something.
Before I left, I already ordered primers to test the FGF10 transcript and expression. Could you,please write a mail to O. and ask if and where she has stored the JF1 and FVB/N RNA or cDNA from thyroid (she extracted it as part of her MSc for the expression array).

Thanks for writing that you feel o.k. with how the project developed and that you are o.k. with everything and don”t regret that you came to Munich. You gave me the nicest and most exciting summer of my life, Ghazal. I never felt so much inspiration, excitement and satisfaction to share with somebody a project and many hours after work as with you.

Take Care

Michael

PS:I go through your text today and send you comments tomorrow

I hope you have a pleasant evening and that you are not only standing in the kitchen. Be careful, if the swedish authorities see this, you will be punished for not following the official policy of womans emancipation. I keep my hope, that the people are more free in their decisions and understand, that doing something in the kitchen can be very pleasant as well. I like it, it has some relation to science and to lab-work, don”t you think so ?
Anyhow, I would also be very happy to know that you enjoy these few days and nights of warm and bright summer. May and June was so awkful, always grey and cold and wet, that even myself (who has an atypical high level of serotonin, dopamin and melatonin) started to get signs of depression. However, there was always the hope to see you the next day, which was and still is the best remedy against sad emotions.
You are completely different, I know this, you have this potential deep inside of you to stop any influence from the outside and concentrate on thoughts and memories and dreams (you call them day-dreams, for me they are end-of-the-day dreams). Maybe you can switch your mind to the angels universe, I would not be surprised.
I think when I saw you the first time sitting in the front raw in the seminar room, you were in exactly this state. It was winter time, cold, wet, streets covered with mud, snow-flakes penetrating the space between neck and coat, shoes did not dry anymore and looked like on a 1st world war battle field. But there you were sitting and filling the seminar room with the aura of an oriental garden. Ghazal, who you think could resist this picture ? Whom you want to blame for immediately feeling the desire to follow you in this other world ?

Now at least the climate changed for the better. After work I always pass along a lake to go swimming. Later I spend the night in the garden and read or play some guitar. The only audience usually is our dog. The rest of the family sits inside and insists they don”t hear. In summer time, southern Germany can be a pleasant place. And winter time is also fine, with a lot of snow and clear sky. What is usually less pleasant are the few month in between.
Ghazal, maybe you consider doing your PhD in Germany. I think the competition is less strong than in Sweden. Talk to Iria or Olena, they will tell you that in Munich it is easy to live and have fun without knowing a lot of german. There are so many high-class institutes in Munich, the two Universities and the Max-Planck-Institutes and Helmholtz also has some very strong groups. And Sweden and Germany are virtually neighbours, only the Baltic Sea between them.

Oh, something else I have to ask you: I bought today this pink Panasonic MP3-player station (the one we looked at last Friday in the Electronic Super-Market).
It was by the way a unique product, something like a prototype. Therefore, I got it without a proper box. Only at home I found out that it is completely incompatible with my Hewlett-Packard Mp3-player. I therefore will give it to you tomorrow. And you keep it (at least till the end of your project), we already know it works perfectly with your IPod.

Sorry, that I wrote once again such an endless mail. And you might consider it complete nonsense.
Take Care
Michael

…………………………………………………………………….

hi michael,
no i dont stand in the kitchen, i dont like to cook.

you should maybe go inside and play for your family then:) but its nice to play for the dog as well i guess.
no i would want to go back to sweden. its better. i will be with my family. im not saying munich is a bad place. but home is always the best place.

you bought exactly the one we saw? why, i dont think your son likes it. but you should keep it. i use my computer and listen to music through it. but it was kind of you.

have a good night!!

/ghazal
……………………………………………………………………..
Dear Ghazal,

You are right. I should more often ask you for your opinion before doing something. The MP3 players design does not suit our sons taste: He only accepts black stuff. He is at an age when boys are very concerned to appeare maskuline, and the slightest risk that somebody might think he loves girls stuff makes him mad (the player is pink, as you remember).

Take Care

Yours Michael

PS: I feel very sorry about the watch. You might think I broke my promise that it will work at the end. Now it appears, it does not. Instead, I only wrote you endless theories about time shifts and angels universe.
If you agree, I”ll open it once again.

Sleep well

When I wrote you yesterday evening “Thanks for the wunderful summer” this was not a spelling mistake !! It was such a nice evening that on its own would give the whole summer 2010 a special glory. You have a very professional way to choose the right radio-program. I did not know that just a few fingertips away from the radiostations I usually hear there is still so nice music. I will try to find some of the titles among my records and bring them to you tomorrow.

Ghazal, you know that in Germany it is illegal to make photographs of somebody without asking his or her permission ? I don”t mean the white swan. First of all, swans are usually very vain, and like to be photographed as often as possible. And in addition to this, he received some cakes as a payment from us. But you forgot that there was also me on the picture, and I was not officially asked for approval. I mean I”m not so concerned that you will do something bad with the pictures (like putting them on facebook to make the entire world laugh about me). But, maybe as a compensation, you could finally agree to have a photograph made of you on the bike wearing the beige coat. It would be more than logical, especially since you said that lady with the bicycle on the french poster does not bear much similarity to yourself. I somehow agree with your opinion, I think you would look much more attractive.

I hope you enjoy the evening

see you tomorrow , take care (don”t kill the spiders, germans belief they can bring you luck).

Yours Michael
…………………………………………………………………………………

hi michael,

im glad i could find a good radiostation that you like.
i did not know its illegal to take photos. only your arm is on the photo. so it doesnt count!:)

i havent seen more spiders and im glad.

see you tomorrow and good night.
………………………………………………………………………………….

Ghazal, my dear.

How nice to read that you keep your sense of homour. About the photo, I”d like to keep the final decision open.

Take Care.

Michael

PS: Ghazal, I just want to tell you: In case of an emergency (candle setting your apartment on fire or a spiderman starting an attack on you), you also can call my mobile number instead of 112. I”ll be at your site for help probably faster than the police.